Human chorionic gonadotropin, Miami


Human chorionic gonadotropin, Miami (hCG) is a chemical created by trophoblast tissue, tissue typically found in early embryos and which will eventually be part of the placenta. There is also a benefit in measuring hCG in a variety of cancers including choriocarcinoma and extra-uterine malignancies.
Human chorionic gonadotropin, Miami is a hormone produced primarily by syncytiotrophoblastic cells of the placenta during pregnancy. The hormone stimulates the corpus luteum to produce progesterone to maintain the pregnancy. Smaller amounts of hCG are also produced in the pituitary gland, the liver, and the colon.
Testing Procedures
Urine Testing
  • Urine is placed in or on a designated receptacle (most commercially available and medical point of care tests)
  • An indicator (typically a colored line or symbol), along with a control, will appear if the test is positive
  • An isolated control line/symbol will be evident if the test is negative
Serum Testing
  • Serum hCG testing is performed in a laboratory equipped with the proper machinery and uses a peripheral blood sample
  • If a hook effect/gestational trophoblastic disease is suspected, the lab should perform a dilution prior to testing
Knowing the utility and variability of different hCG assays is clinically relevant to a wide range of medical providers. False positive and false negative testing has a large impact on patient care. All providers in a patient care team should be aware of common limitations in testing, for example, urine assay false positives with hematuria, false negatives with dilute urine, along with more obscure but still very relevant causes of inaccurate testing. 
Side Effect of HCG
Some women using human chorionic gonadotropin, Miami (HCG) have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. 
·         severe pelvic pain;
·         swelling of the hands or legs;
·         stomach pain and swelling;
·         shortness of breath;
·         weight gain;
·         diarrhea;
·         nausea or vomiting; or
·         urinating less than normal.

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